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Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health de John C. Lucchesi

Descripción - Reseña del editor Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information. Biografía del autor John Lucchesi obtained a Ph.D. in Genetics from the University of California at Berkeley. Following postdoctoral training in the Institute of Molecular Biology at the University of Oregon, he joined the faculty of the University of North Carolina in Chapel Hill, where he rose to the rank of Cary C. Boshamer Professor of Biology and Genetics. He was appointed Adjunct Professor of Genetics at Duke University and was named Senior Fellow of Churchill College, Cambridge University, UK. In 1990, he joined the faculty of the Biology Department at Emory University as Asa G. Candler Professor of Biology and Chair. Dr Lucchesi is a fellow of the AAAS, a former President of the Genetics Society of America and was named Vice-President of the XVII International Congress of Genetics. His research laboratory has focused on the regulation of transcription, the functional architecture of chromatin and the genetic regulation of development.

Detalles del Libro

• Name: Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health
  
• Autor: John C. Lucchesi
  
• Categoria: Libros,Libros universitarios y de estudios superiores,Medicina y ciencias de la salud
  
• Tamaño del archivo: 17 MB
  
• Tipos de archivo: PDF Document
  
• Idioma: Español
  
• Archivos de estado: AVAILABLE
  

Lee un libro Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health de John C. Lucchesi Libros Gratis en EPUB

Epigenetics, Nuclear Organization & Gene Function: With ~ Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health Paperback – March 9, 2019 by John C. Lucchesi (Author) 5.0 out of 5 stars 2 ratings. See all formats and editions Hide other formats and editions. Price New .

Epigenetic control of nuclear architecture ~ The distribution of 5mC in discrete heterochromatic foci associated with the nuclear envelope is best observed in tissues, where the spatial and functional organization of the nuclear architecture is constrained by the three-dimensional network of cell-cell and cell-substrate interactions that are required to maintain the homeostasis of the tissue (Fig. (Fig.2b). 2b).

Epigenetics, Nuclear Organization & Gene Function: With ~ Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. Epigenetic changes, consisting principally of DNA methylation, histone modifications and non-coding RNAs, maintain and modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences.

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Epigenetics - Google Libros ~ The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms .

epigenetics / Definition, Inheritance, & Disease / Britannica ~ Epigenetics, the study of the chemical modification of specific genes or gene-associated proteins of an organism. Epigenetic modifications can define how the information in genes is expressed and used by cells. The term epigenetics came into general use in the early 1940s, .

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How epigenetics integrates nuclear functions ~ The recent discovery that DNA methylation alterations have an impact on both nuclear organization and histone modification patterns also supports this view (Espada et al, 2004). F. Azorin (Barcelona, Spain) showed how Drosophila dodecasatellite protein 1 (DDP1) acts both by binding to single-stranded nucleic acids and by maintaining heterochromatin structure.

Epigenetics, Nuclear Organization & Gene Function - John C ~ Epigenetics, Nuclear Organization & Gene Function With implications of epigenetic regulation and genetic architecture for human development and health John C. (Asa Griggs Candler Professor Emeritus, Asa Griggs Candler Professor Emeritus, Department of Biology, Emory University, Atlanta GA, USA) Lucchesi

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Epigenetics definición y significado / Diccionario Inglés ~ Epigenetics definición: the study of heritable changes that occur without a change in the DNA sequence / Significado, pronunciación, traducciones y ejemplos

Epigenetics - Simple English Wikipedia, the free encyclopedia ~ Epigenetics is the study of changes in gene activity which are not caused by changes in the DNA sequence. It is the study of gene expression, the way genes bring about their phenotypic effects.. These changes in gene activity may stay for the remainder of the cell's life and may also last for many generations of cells, through cell divisions.However, there is no change in the underlying DNA .

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Epigenetics / Definition of Epigenetics by Merriam-Webster ~ Epigenetics definition is - the study of heritable changes in gene function that do not involve changes in DNA sequence. How to use epigenetics in a sentence.

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Epigenomics - Future Medicine ~ Epigenetics and lifestyle. Jorge Alejandro Alegría-Torres, Andrea Baccarelli & Valentina Bollati; Vol. 3, No. 3 30 Jun 2011. Methyl-CpG-binding domain proteins: readers of the epigenome. Qian Du, Phuc-Loi Luu, Clare Stirzaker & Susan J Clark; Vol. 7, No. 6 30 Apr 2015. Epigenetic .

Epigenetics: Fundamentals, History, and Examples / What is ~ What is Epigenetics? Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age .

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Epigenética: qué es, para qué sirve y qué estudia ~ La epigenética es un sistema de regulación que controla la expresión de los genes sin alterar la secuencia de ADN. Descubre para qué sirve y cómo funciona.

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Epigenetics - QIAGEN ~ This may have significant implications in epigenetics, . The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324, 929. Tahiliani, M., et al. (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.

Impact of nuclear organization and dynamics on epigenetic ~ Epigenetic mechanisms that are highly responsive to interoceptive and environmental stimuli mediate the proper execution of complex genomic programs, such as cell type–specific gene transcription and.